Appleton Luff was founded in Geneva and Brussels. Members of its Geneva office work closely on issues involving Geneva-based international organisations. They focus on matters involving trade, health, labour, intellectual property, human rights, dispute settlement, and development.  Its attorneys combine many years of legal practice, with practical experience working for, and with, Geneva-based international organisation, including the ILO, WHO, and WTO. They have travelled world-wide in the service of their clients.

Appleton Luff's Geneva office is notable for its work with health care and life science companies, and with governments seeking to reform trade and labour-related practices. In addition to offering highly rated legal services, its attorneys offer consulting services on policy matters, and technical assistance programmes - including judicial training, labour law reform, trade law reform, and rule of law issues.